Figure 5 from Characterization of age-associated gene expression changes in mouse sweat glands | Semantic Scholar (2024)

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It is found that the forkhead transcription factor, FoxA1, is required to generate mouse sweating capacity and is inferred to regulate two corresponding features of sweat secretion, which can be pharmaceutical targets to defend against hyperthermia and alleviate defective thermoregulation in the elderly.

Findings support the evidence of age-related deterioration in both autonomic and subjective responses in the heat and highlight the lower extremities as the most affected body region.

This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.

The results suggest that in older men the lower thigh m˙sw observed during the last half of the heat test was possibly due to age-related modifications of peripheral mechanisms involving the sweat glands and surrounding tissues, and not due to a change in the central drive to sudomotor function.

Foxa1 was consistently expressed during the late stages of ESGs and had a significant role in secretory coil maturation during sweat secretion, providing evidence that Foxa1 may influence ESG development through transcriptional regulation of NKA expression.

Climate change has already had an impact and is responsible for 37% of warm-season heat-related deaths between 1991 and 2018, with increases in mortality observed globally, which supports the urgent need for more ambitious mitigation and adaptation strategies to minimize the public health impacts of climate change.

It is unclear whether and how the structure of sweat glands changes during aging, because the 3D structure is complex and inaccessible.

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